Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2

J Med Chem. 1998 May 21;41(11):1741-4. doi: 10.1021/jm970856n.
No abstract available

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • GRB2 Adaptor Protein
  • Hydrogen Bonding
  • Ligands
  • Models, Molecular
  • Oligopeptides / chemistry
  • Oligopeptides / metabolism
  • Oligopeptides / pharmacology*
  • Protein Conformation
  • Proteins / antagonists & inhibitors*
  • Proteins / metabolism
  • Structure-Activity Relationship
  • src Homology Domains*

Substances

  • 3-amino-phenylmethoxycarbonyl-phosphotyrosyl-1-aminocyclohexanecarbonyl-asparaginamide
  • Adaptor Proteins, Signal Transducing
  • GRB2 Adaptor Protein
  • Ligands
  • Oligopeptides
  • Proteins